This week’s two stories have nothing in common on the surface — one involves radiation-sterilized flies, a Texas air base, and a $100 million federal challenge grant; the other involves a Queensland PhD candidate, 42 cattle operations, and a statistical method called LASSO regression. What they share is a refusal to be flashy about something genuinely important.
On April 17, Secretary of Agriculture Brooke Rollins and a U.S. Army Corps of Engineers general turned dirt at Moore Air Base in Edinburg, Texas — the first groundbreaking for a domestic sterile New World Screwworm production facility since the original eradication campaign in the 1960s. It is the most consequential beef biosecurity infrastructure decision in a generation, and it has been largely underreported because it’s a story about flies, not software.
Meanwhile, out of the Northern Beef Research Update Conference in Brisbane, a machine learning profitability analysis from the University of Queensland quietly produced the most practically useful finding we’ve seen all quarter: a ranked list of the variables that actually drive cattle enterprise income, with statistical confidence levels attached. The answer isn’t surprising. The ranking is.
In Simple Terms covers the Australian research — what the LASSO analysis found, what the ranked drivers mean for management decisions, and why a machine learning method produced a more honest answer than three decades of extension advice. The Deep Dive covers the screwworm story in full: the Sterile Insect Technique, what the new production infrastructure means for the border closure and supply chain, and how the $100 million Grand Challenge changes the commercial opportunity for producers and agtech innovators alike.
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BEST LINKS
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Sterile Flies at the Heart of the New World Screwworm Defense as They Near the US Border | Oklahoma Farm Report
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AI: How the Gloves Are Coming Off in the Cattle Industry | Beef Central
At Australia's Northern Beef Research Update Conference, producers, scientists and industry leaders shared real-world examples of AI in the paddock — from machine learning identifying the top drivers of enterprise profitability to virtual fencing and an AI-plus-VR platform supporting Indigenous peer-to-peer learning in remote cattle country. A wide-angle view of where AI is actually landing in beef operations today.
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IN SIMPLE TERMS
What Actually Drives Beef Profitability: Ranked
Australian researchers ran machine learning on the books of 42 cattle operations. Here’s the ranked list they produced — and why the order matters more than the list.
What was the research?
At the Northern Beef Research Update Conference in Brisbane last month, researchers Kieren McCosker and Ian McLean from the University of Queensland and Bush Agribusiness presented a LASSO regression analysis of long-term performance data from 42 northern Australian cattle enterprises [1][2][3]. LASSO is a machine learning method designed to identify which variables in a large dataset actually drive an outcome — and which ones are noise. Applied to cattle enterprise profitability, it produced a ranked list of the management variables that matter most, with statistical confidence levels attached to each.
What did it find?
Productivity measured in kilograms per adult equivalent — the total weight of cattle sold divided by the metabolic demand of the herd carrying that inventory — was the single strongest driver of profitability, by a significant margin [3]. The next most important variables were male sale price, female sale price, and the proportion of the herd sold as males, each with p-values below 0.001. Female purchases and heavier male purchase weights showed negative correlations with herd income.
Put plainly: how efficiently your herd converts grass into saleable beef is the master variable. The price you receive for that beef matters, but it matters less. The composition of what you sell matters. And buying females or heavy males is, on average, a drag on income rather than an investment in it.
Why does the method matter?
Extension agents have been telling producers that productivity matters for decades. What LASSO added is the honest ranking. Machine learning didn’t discover a new truth — it stripped out the noise around a known truth and forced the variables into an ordered hierarchy. That hierarchy is the useful output. If you only have management attention for three things, the research says: optimize kg per adult equivalent, maximize male sale price, and examine your male-to-female sales ratio. Everything else is second-order.
The negative finding on female purchases is worth sitting with. It challenges a common assumption that buying quality replacement females is a straightforward investment in herd value. At the enterprise level, across 42 operations, the data says it’s more complicated than that.
What’s the U.S. connection?
New Mexico State University’s Professor Derek Bailey keynoted the conference, presenting work on tracking technology, accelerometers, and AI-assisted grazing distribution that maps directly onto public-land operations in the American West [1]. The NBRUC proceedings are publicly available through NABRC, and Bailey is approachable for producers interested in the grazing distribution research specifically.
The broader connection is methodological. LASSO regression and similar approaches can be applied to any dataset of sufficient size — and U.S. operations participating in programs like the Texas A&M CGRM Resilience Network (now partnered with 420 ranches across 17 states) are generating exactly the kind of long-run performance data that makes this analysis possible. The tool isn’t exotic. The willingness to apply it honestly to your own books is.
THE RANKED DRIVERS OF CATTLE ENTERPRISE PROFITABILITY
Productivity (kg per adult equivalent) — by far the strongest signal
Male sale price — p < 0.001
Female sale price — p < 0.001
Proportion of males sold — p < 0.001
Negative correlation: female purchases and heavier male purchase weights
Source: McCosker & McLean, University of Queensland + Bush Agribusiness, NBRUC 2026 [3]
SOURCES
[1] Beef Central, “AI: How the gloves are coming off in the cattle industry,” April 2026. beefcentral.com
[2] Northern Beef Research Update Conference (NBRUC) 2026, Brisbane. Proceedings available via NABRC.
[3] McCosker, K. and McLean, I., LASSO regression profitability research, University of Queensland + Bush Agribusiness. Presented NBRUC 2026.

DEEP DIVE
The 1960s Playbook Goes Digital
USDA just broke ground on the first domestic sterile screwworm fly factory since the original eradication campaign. Here’s why it’s the most important beef biosecurity infrastructure decision in a generation — and what the $100 million Grand Challenge means for producers and innovators.
On April 17, Secretary of Agriculture Brooke Rollins and Lieutenant General William “Butch” Graham of the U.S. Army Corps of Engineers turned dirt at Moore Air Base in Edinburg, Texas [5]. The groundbreaking marks the first domestic sterile New World Screwworm fly production facility built on American soil since the 1960s. The choice of Moore Air Base is not coincidental — it is the same installation that anchored the original eradication campaign six decades ago. The symbolism is deliberate, and so is the engineering.
This story has been underreported because it involves flies, not software, and because the underlying technology is decades old. Neither of those things makes it less consequential. This is the most significant beef biosecurity infrastructure investment in a generation, and every producer with cattle in the southern tier needs to understand what it means.
The Biology Behind the Strategy
The Sterile Insect Technique works because of a single behavioral fact: female New World Screwworm flies mate exactly once. If a female mates with a sterile male — one that has been radiation-sterilized but is otherwise healthy and competitive — she produces eggs that never hatch. Her reproductive contribution to the population is zero. Flood a target area with enough sterile males, and the math eventually overwhelms the wild population. It collapses.
This is the same technique that drove screwworm out of the continental United States by 1966 and out of Central America by 2000. It requires no chemical application, produces no resistance, and has no off-target effects on other species. It is biological software — the screwworm’s own mating behavior is the exploit, and sterile males are the patch [4].
The limitation has always been production scale. You need enough sterile males in the target area to reliably intercept wild females before they find a wild male. During the original eradication campaign, peak production reached approximately 500 million sterile flies per week — a figure that required industrial-scale rearing, irradiation, and aerial dispersal infrastructure.
What the New Infrastructure Adds
Current combined output from the Panama COPEG facility — the only major sterile fly production site currently operating — sits at roughly 100 million sterile flies per week [4][5]. Once Moore Air Base comes online alongside the modernized Mexican facility at Metapa, combined capacity will approach approximately 500 million per week, matching the eradication-era peak. That production volume, deployed against a northern Mexico and southern U.S. screwworm population, gives containment authorities the numerical density needed to actually suppress the population rather than merely slow its advance.
Three technology threads inside the April 8 APHIS Response Playbook and the April 17 groundbreaking deserve specific producer attention. First, production scale-up: the radiation-sterilization biotech is mature, but the logistics of rearing and irradiating hundreds of millions of flies weekly and dispersing them across targeted zones is a modern industrial engineering challenge. Contracts to build it out are flowing now, and the supply chain being created is new [4]. Second, a continental surveillance grid: APHIS has deployed more than 8,000 traps across Texas, Arizona, and New Mexico, with case-detection maps updated twice weekly [4]. This is, in effect, an intrusion detection system for a parasite — distributed sensors, scheduled data pulls, centralized analysis. Third, and most immediately relevant for producers and agtech innovators: the Grand Challenge.
The $100 Million Opportunity
USDA has opened up to $100 million in competitive awards for innovations in sterile-fly production efficiency, detection technology, preparedness planning, and outbreak response [4]. The program is explicitly designed to attract agtech startups, university labs, and research institutions that can accelerate any part of the screwworm response system.
For producers with working relationships with university extension offices or research stations, this is a moment to position your operation as a field demonstration site. Federal challenge grants of this scale almost always move faster when applicants can show a real-world testing environment. A producer in southern Texas or New Mexico who can offer access and operational data to a university lab pursuing a detection technology grant is providing something genuinely valuable to that application.
The FDA has also issued Emergency Use Authorizations for topical sprays to prevent and treat screwworm infestations [6]. The March 10 formulation — with a 10-day milk withdrawal time — is the material detail for dairy-beef crossover operations. If you haven’t reviewed your screwworm preparedness protocols since last year’s border closure, the EUA approval is the practical starting point.
The Supply Chain Context
The U.S.–Mexico border has been closed continuously to live cattle imports since May 2025 [7]. That is more than a million head per year removed from the domestic supply chain — cattle that historically account for roughly 62% of U.S. live cattle imports — at precisely the moment the U.S. beef cow herd sits at its lowest inventory in 75 years. The $250 fed cattle futures that producers are pricing around right now are, in part, a direct consequence of that closure.
The groundbreaking at Moore Air Base is USDA’s signal that the path back to an open border runs through screwworm eradication — and that they are building the infrastructure to get there at scale, not waiting for the parasite to cross the Rio Grande before responding. That is the right engineering posture. The border will not reopen until the screwworm threat is demonstrably contained. The fly factory is what contains it.
BY THE NUMBERS
$100M — USDA Grand Challenge funding pool, open to agtech innovators [4]
500M — Target weekly sterile-fly production once all three facilities are operational [5]
8,000+ — Surveillance traps deployed across TX, AZ, and NM [4]
1M+ — Mexican cattle per year removed from U.S. supply since May 2025 border closure [7]
75-year low — Current U.S. beef cow herd inventory
SOURCES
[4] USDA-APHIS, “New World Screwworm Response Playbook,” April 8, 2026. aphis.usda.gov
[5] USDA Office of the Secretary, Groundbreaking remarks, Moore Air Base, Edinburg, Texas, April 17, 2026.
[6] FDA, Emergency Use Authorization for topical screwworm spray (10-day milk withdrawal formulation), March 10, 2026.
[7] USDA Agricultural Marketing Service, Border closure cattle import data, May 2025–present.
WRAPPING UP
What We’re Watching
On screwworm: the first production milestone to watch is any announced timeline for Moore Air Base to reach operational capacity. The delta between current output (100 million flies per week from COPEG) and target capacity (500 million) is where the border closure lives. We’ll track that number as the facility build-out proceeds. We’re also watching Grand Challenge award announcements — the first grants will signal which detection and production technology approaches USDA considers most promising.
On the LASSO research: the findings out of NBRUC are unpublished as formal peer-reviewed work. We’ll follow McCosker and McLean’s publication timeline and report when the full methodology and dataset are available for U.S. extension review. If your operation participates in a long-run performance data program, this is the kind of analysis worth requesting from your university extension partner.
One more item worth noting before next week: on April 10, Purdue Veterinary Medicine announced a four-year, $650,000 USDA-NIFA award to Dr. Viju Pillai’s lab to investigate early embryonic loss in cattle — specifically, the trophoblast proteins at the embryo-uterine interface during the first two to three weeks of pregnancy. Standard pregnancy detection tools don’t deliver a useful signal until 28 to 35 days. Pillai’s research is building stem-cell-derived models that open a window into that invisible early period. Commercialization — think blood-test kits and chute-side assays — typically follows this kind of foundational science on a five-to-seven-year arc. It’s not a tool for this year’s breeding season. It is the kind of early-stage, USDA-funded research that becomes next decade’s standard of care. Worth knowing it exists.
BeefTech.News – Keeping you ahead of the herd.
Half a billion sterile flies a week. A machine learning ranking of what actually moves the needle. Neither is on the cover of a tech magazine. Both will matter to your operation long after this week’s headlines are forgotten. Forward this to a producer who thinks in decades.

